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Medline ® Abstract for Reference 28

of 'Management of bladder dysfunction in children'

28
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Spectrum of central anticholinergic adverse effects associated with oxybutynin: comparison of pediatric and adult cases.
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Gish P, Mosholder AD, Truffa M, Johann-Liang R
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J Pediatr. 2009;155(3):432.
 
We reviewed Food and Drug Administration postmarketing reports of central nervous system (CNS) anticholinergic effects in association with oxybutynin. Taking domestic usage by age group into account, there is a disproportionately higher number of CNS adverse event cases reported in pediatric patients as compared with adult patients. CNS stimulation was prominent in the pediatric cases.
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Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, The United States Food and Drug Administration, Silver Spring, MD 20993, USA. paula.gish@fda.hhs.gov
PMID