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Medline ® Abstract for Reference 24

of 'Magnetic resonance imaging of the hepatobiliary tract'

Magnetic resonance imaging quantification of liver iron.
Sirlin CB, Reeder SB
Magn Reson Imaging Clin N Am. 2010 Aug;18(3):359-81, ix.
Iron overload is the histologic hallmark of hereditary hemochromatosis and transfusional hemosiderosis but also may occur in chronic hepatopathies. This article provides an overview of iron deposition and diseases where liver iron overload is clinically relevant. Next, this article reviews why quantitative noninvasive biomarkers of liver iron would be beneficial. Finally, we describe current state-of-the-art methods for quantifying iron with MR imaging and review remaining challenges and unsolved problems.
Liver Imaging Group, Department of Radiology, University of California San Diego, 408 Dickinson Street, San Diego, CA 92103-8226, USA. csirlin@ucsd.edu