Medline ® Abstract for Reference 53
of 'Lynch syndrome (hereditary nonpolyposis colorectal cancer): Clinical manifestations and diagnosis'
Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.
Ladabaum U, Wang G, Terdiman J, Blanco A, Kuppermann M, Boland CR, Ford J, Elkin E, Phillips KA
Ann Intern Med. 2011;155(2):69.
BACKGROUND: Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine.
OBJECTIVE: To estimate the effectiveness and cost-effectiveness of strategies to identify the Lynch syndrome, with attention to sex, age at screening, and differential effects for probands and relatives.
DESIGN: Markov model that incorporated risk for colorectal, endometrial, and ovarian cancers.
DATA SOURCES: Published literature.
TARGET POPULATION: All persons with newly diagnosed colorectal cancer and their relatives.
TIME HORIZON: Lifetime.
PERSPECTIVE: Third-party payer.
INTERVENTION: Strategies based on clinical criteria, prediction algorithms, tumor testing, or up-front germline mutation testing, followed by tailored screening and risk-reducing surgery.
OUTCOME MEASURES: Life-years, cancer cases and deaths, costs, and incremental cost-effectiveness ratios.
RESULTS OF BASE-CASE ANALYSIS: The benefit of all strategies accrued primarily to relatives with a mutation associated with the Lynch syndrome, particularly women, whose life expectancy could increase by approximately 4 years with hysterectomy and salpingo-oophorectomy and adherence to colorectal cancer screening recommendations. At current rates of germline testing, screening, and prophylactic surgery, the strategies reduced deaths from colorectal cancer by 7% to 42% and deaths from endometrial and ovarian cancer by 1% to 6%. Among tumor-testing strategies, immunohistochemistry followed by BRAF mutation testing was preferred, with an incremental cost-effectiveness ratio of $36,200 per life-year gained.
RESULTS OF SENSITIVITY ANALYSIS: The number of relatives tested per proband was a critical determinant of both effectiveness and cost-effectiveness, with testing of 3 to 4 relatives required for most strategies to meet a threshold of $50,000 per life-year gained. Immunohistochemistry followed by BRAF mutation testing was preferred in 59% of iterations in probabilistic sensitivity analysis at a threshold of $100,000 per life-year gained. Screening for the Lynch syndrome with immunohistochemistry followed by BRAF mutation testing only up to age 70 years cost $44,000 per incremental life-year gained compared with screening only up to age 60 years, and screening without an upper age limit cost $88,700 per incremental life-year gained compared with screening only up to age 70 years.
LIMITATION: Other types of cancer, uncertain family pedigrees, and genetic variants of unknown significance were not considered.
CONCLUSION: Widespread colorectal tumor testing to identify families with the Lynch syndrome could yield substantial benefits at acceptable costs, particularly for women with a mutation associated with the Lynch syndrome who begin regular screening and have risk-reducing surgery. The cost-effectiveness of such testing depends on the participation rate among relatives at risk for the Lynch syndrome.
PRIMARY FUNDING SOURCE: National Institutes of Health.
Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA. email@example.com