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Lymphomatoid papulosis

INTRODUCTION

Lymphomatoid papulosis (LyP) is a recurrent, self-healing papulonodular skin eruption with histologic features of a CD30+ malignant T cell lymphoma [1,2]. LyP is part of the group of cutaneous CD30+ lymphoproliferative disorders (LPDs) that includes primary cutaneous anaplastic large cell lymphoma (pcALCL) and borderline CD30+ lesions.

LyP is characterized by a chronic course, lasting years or decades. Grouped or disseminated papules and nodules develop and spontaneously regress over weeks to months (picture 3D). Patients with LyP have an excellent prognosis, although they are at increased risk of developing a second cutaneous or nodal lymphoma, such as mycosis fungoides, pcALCL, or Hodgkin lymphoma.

This topic will discuss the clinical presentation, diagnosis, and treatment of LyP. Other cutaneous T cell lymphomas are discussed separately.

(See "Clinical manifestations, pathologic features, and diagnosis of anaplastic large cell lymphoma, ALK positive".)

(See "Clinical manifestations, pathologic features, and diagnosis of mycosis fungoides".)

                               

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Literature review current through: Jul 2014. | This topic last updated: Jul 23, 2014.
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