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Jose Dario Martinez Villarreal, MD
Fabio Francesconi, MD
Section Editor
Ted Rosen, MD
Deputy Editor
Abena O Ofori, MD


Lobomycosis is a chronic fungal infection of the skin and subcutaneous tissue that primarily occurs in tropical climates of Latin America. The causative organism is Lacazia loboi (formerly Loboa loboi), a dimorphic fungus found in soil, vegetation, and water. Infection occurs through traumatic implantation of the fungus into the skin.

Lobomycosis affects both humans and dolphins. The most common presentation in humans consists of slow-growing, keloid-like papules, nodules, or plaques in a localized area on exposed skin (picture 1A-C). Other manifestations of lobomycosis include ulcerated, infiltrative, verrucous, gumma-like, multifocal, and disseminated lesions.

Although lobomycosis is the accepted term for this disorder, a variety of other names have been used to refer to lobomycosis [1]. Examples include Jorge Lobo's disease, Jorge Lobo mycosis, Jorge Lobo blastomycosis, Amazonic pseudolepromatous blastomycosis, miraip or piraip ("burning" in the Tupi language), Caiabi leprosy, and lacaziosis.

The clinical features, diagnosis, and management of lobomycosis will be reviewed here.


The taxonomy of the fungus that causes lobomycosis has changed multiple times since the first description of the disease [2-7]. The general consensus is that Lacazia loboi is the preferred nomenclature [8]. L. loboi is a dimorphic fungus that may exist in a saprophytic phase in soil, vegetation, and water [9]. Molecular analyses have demonstrated a relationship between L. loboi and other fungal members of the order Onygenales, including Paracoccidioides brasiliensis [10]. Attempts to culture L. loboi in vitro have failed.


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Literature review current through: Sep 2016. | This topic last updated: Jul 6, 2016.
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