- Karen J Tietze, PharmD
Karen J Tietze, PharmD
- Professor of Clinical Pharmacy
- Philadelphia College of Pharmacy
- University of the Sciences in Philadelphia
- Scott Manaker, MD, PhD
Scott Manaker, MD, PhD
- Section Editor — Critical Care
- Professor of Medicine
- University of Pennsylvania School of Medicine
Liquid ventilation (LV) is a technique of mechanical ventilation in which the lungs are insufflated with an oxygenated perfluorochemical liquid rather than an oxygen-containing gas mixture. The use of perfluorochemicals, rather than nitrogen, as the inert carrier of oxygen and carbon dioxide offers a number of theoretical advantages for the treatment of acute lung injury, including:
●Reducing surface tension by maintaining a fluid interface with alveoli
●Opening of collapsed alveoli by hydraulic pressure with a lower risk of barotrauma
●Providing a reservoir in which oxygen and carbon dioxide can be exchanged with pulmonary capillary blood
●Functioning as a high efficiency heat exchanger
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