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Leukocyte-adhesion deficiency

Amos Etzioni, MD
Section Editor
Luigi D Notarangelo, MD
Deputy Editor
Anna M Feldweg, MD


Leukocyte trafficking from the bloodstream to tissue is important for the continuous surveillance of foreign antigens, as well as for rapid leukocyte accumulation at sites of inflammatory response or tissue injury. Leukocyte emigration to sites of inflammation is a dynamic process, involving multiple steps in an adhesion cascade. Various adhesion molecules are expressed on both resting and stimulated endothelial cells and leukocytes.

Defects in a number of these adhesion molecules result in recognized clinical syndromes. Three leukocyte-adhesion deficiency (LAD) syndromes have been delineated, and a fourth category of other neutrophil adhesion defects has been proposed [1]:

LAD I, in which the beta-2 integrin family is deficient or defective.

LAD II, in which the fucosylated carbohydrate ligands for selectins are absent.

LAD III, in which activation of all beta integrins (1, 2, and 3) is defective.

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Literature review current through: Sep 2017. | This topic last updated: Mar 28, 2017.
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