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Left ventricular hypertrophy and arrhythmia

Philip J Podrid, MD, FACC
Section Editor
George L Bakris, MD
Deputy Editor
Brian C Downey, MD, FACC


Data, primarily from the Framingham Heart Study, have identified electrocardiographic left ventricular hypertrophy (LVH) as a blood pressure-independent risk for sudden cardiac death (SCD) [1,2], acute myocardial infarction [3], and other cardiovascular morbidity and mortality [4]. (See "Clinical implications and treatment of left ventricular hypertrophy in hypertension" and "Electrocardiographic diagnosis of left ventricular hypertrophy".)

These relationships can be illustrated by the following findings in patients with a definite electrocardiographic pattern of LVH:

A 59 percent overall mortality at 12 years [2]

A threefold increase in the risk of developing overt coronary heart disease at 14 years, even after adjustments for concomitant hypertension are made [3]

A sixfold increase in sudden cardiac death among men and a threefold increase in women [3]


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Literature review current through: Feb 2015. | This topic last updated: Dec 8, 2014.
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