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Laser and light therapy for cutaneous hyperpigmentation

Andrei Metelitsa, MD, FRCPC
Thomas Rohrer, MD
Kenneth A Arndt, MD
Section Editor
Jeffrey S Dover, MD, FRCPC
Deputy Editor
Abena O Ofori, MD


Lasers and intense pulsed light are useful for the treatment of a wide variety of disorders characterized by the presence of cutaneous hyperpigmentation. The mechanisms by which these therapies improve hyperpigmentation include photothermal, photomechanical, and ablative effects.

Thorough knowledge of the principles that govern the interaction between light and skin is essential for the successful and safe clinical application of lasers and intense pulsed light. Knowledge of the lesion type and lesional histopathologic characteristics are critical for the selection of an appropriate light-based therapy.

The principles of laser and intense pulsed light therapy for hyperpigmented skin lesions, the lasers used for this indication, and the therapeutic options for select disorders of hyperpigmentation will be discussed here. The general principles of medical lasers and more information on the principles of treatment of cutaneous lesions with laser and intense pulsed light are reviewed elsewhere. (See "Basic principles of medical lasers" and "Principles of laser and intense pulsed light for cutaneous lesions".)


The use of laser and intense pulsed light therapy for cutaneous hyperpigmentation is based upon the clinical application of the theory of selective photothermolysis, a theory that describes the mechanism by which light can be used to exert specific effects on the skin [1]. (See "Principles of laser and intense pulsed light for cutaneous lesions", section on 'Selective photothermolysis'.)

The basic principles of selective photothermolysis are as follows [1]:


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Literature review current through: Sep 2016. | This topic last updated: Sep 7, 2015.
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