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Medline ® Abstract for Reference 84

of 'Laboratory tests to support the clinical diagnosis of anaphylaxis'

84
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Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis.
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Nishio H, Takai S, Miyazaki M, Horiuchi H, Osawa M, Uemura K, Yoshida K, Mukaida M, Ueno Y, Suzuki K
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Int J Legal Med. 2005;119(6):331.
 
Chymase, a serine protease, is stored mainly in secretory granules of human mast cells. Serum chymase concentration was examined in 8 autopsy cases with anaphylaxis as well as in 104 control cases without anaphylaxis. It was detected in all 8 cases with anaphylaxis (range 3-380 ng/ml, mean 89.8 ng/ml), while it was detected in only 2 of the 104 controls and was below a detectable level (<3 ng/ml) in the other 102. Serum tryptase levels are known to be a diagnostic indicator of anaphylaxis, therefore the relationship between serum chymase and tryptase levels was investigated in the 8 cases of anaphylactic death; a significant positive correlation was found (r=0.826, p=0.011). Furthermore, chymase was shown to be quite stable in serum. These results showed that measurement of serum chymase levels might be an additional tool for postmortem diagnosis of anaphylaxis.
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Department of Legal Medicine, Osaka Medical College, Takatsuki 569-8686, Japan. leg010@art.osaka-med.ac.jp
PMID