Medline ® Abstract for Reference 69
of 'Laboratory tests to support the clinical diagnosis of anaphylaxis'
Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites.
Keyzer JJ, van Saene HK, van den Berg GA, Wolthers BG
Agents Actions. 1984;15(3-4):238.
Urinary excretions of histamine, N tau-methylhistamine and N tau-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of N tau-methylhistamine and N tau-methylimidazoleacetic acid decreased to a small though significant degree (about 15-20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.