Laboratory evaluation of neutrophil disorders
- Thomas D Coates, MD
Thomas D Coates, MD
- Professor of Pediatrics and Pathology
- University of Southern California School of Medicine
The polymorphonuclear neutrophil (PMN) is the primary defense against bacterial and fungal invasion. Defects of neutrophil number and function commonly present with recurrent and severe bacterial and fungal infections, often involving the skin and respiratory tract as well as deep tissue sites.
This topic reviews the laboratory evaluation of neutropenia and neutrophil dysfunction. The overall approach to the patient with neutropenia, including a discussion of indications for bone marrow evaluation and the individual neutrophil function defects, are discussed separately:
●Neutropenia (children) – (See "Overview of neutropenia in children and adolescents".)
●Neutropenia (adults) – (See "Approach to the adult with unexplained neutropenia".)
●Neutrophil dysfunction – (See "Primary disorders of phagocytic function: An overview".)
- Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood 2016; 127:2173.
- Dinauer MC, Coates TD. Disorders of phagocyte function. In: Hematology: Basic Principles and Practice, 6th ed, Hoffman R, Benz EJ Jr, Silberstein LE, et al. (Eds), Elsevier, Philadelphia 2012. p.655.
- GeneDX: www.genedx.com (Accessed on June 02, 2011).
- Correlagen Diagnostics: www.correlagen.com (Accessed on June 02, 2011).
- In the United States, Children's Hospitals with expertise in diagnostic testing for primary immunodeficiencies include Cincinnati Children's Hospital Medical Center (www.cincinnatichildrens.org), Children's Hospital of Wisconsin in Milwaukee (www.chw.org) and Seattle Children's Hospital (www.seattlechildrens.org).
- TESTING FOR NEUTROPENIA
- Overview of causes (neutropenia)
- Bone marrow evaluation
- Tests for immune neutropenia
- TESTING FOR NEUTROPHIL DYSFUNCTION
- Overview of causes (neutrophil dysfunction)
- Presentation and indications for evaluation
- Choice of assay
- Challenges in more specialized neutrophil function testing
- Genetic testing