Iron overload syndromes other than hereditary hemochromatosis
- Stanley L Schrier, MD
Stanley L Schrier, MD
- Editor-in-Chief — Hematology
- Section Editor — Myeloproliferative Disorders; Red Cell Disorders
- Professor of Medicine
- Stanford University School of Medicine
- Bruce R Bacon, MD
Bruce R Bacon, MD
- Professor of Internal Medicine
- Saint Louis University School of Medicine
This topic review will focus on the diagnosis and treatment of the iron overload syndromes other than gene mutations associated with hereditary hemochromatosis (HH), which affect the iron absorption and release pathway.
The following issues are discussed in more detail separately:
●Clinical manifestations of iron overload (see "Clinical manifestations and diagnosis of hereditary hemochromatosis")
●General approach to suspected iron overload (see "Approach to the patient with suspected iron overload")
●Iron chelation therapy (see "Chelation therapy for thalassemia and other iron overload states")
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- PRINCIPLES OF NORMAL IRON BALANCE
- ANEMIA DUE TO INEFFECTIVE ERYTHROPOIESIS
- Mechanism for increased iron absorption
- PORPHYRIA CUTANEA TARDA
- Liver disease
- HFE gene mutations
- HCV infection
- LIVER IRON OVERLOAD WITH NORMAL TRANSFERRIN SATURATION
- AFRICAN IRON OVERLOAD
- TRANSFUSIONAL IRON OVERLOAD
- REPEATED PARENTERAL IRON INFUSION
- Intravenous iron preparations
- Intravenous hematin/hemin
- NEONATAL OR PERINATAL IRON OVERLOAD
- INSULIN RESISTANCE
- EXTREMELY HIGH FERRITIN LEVELS
- CHELATION THERAPY