- Karin Leder, MBBS, FRACP, PhD, MPH, DTMH
Karin Leder, MBBS, FRACP, PhD, MPH, DTMH
- Section Editor — Travel Medicine
- Head of Infectious Diseases Unit
- Monash University, Australia
- Peter F Weller, MD, MACP
Peter F Weller, MD, MACP
- Editor-in-Chief — Infectious Diseases
- Section Editor — Tropical Medicine
- William Bosworth Castle Professor of Medicine
- Harvard Medical School
- Professor of Immunology and Infectious Diseases
- Harvard T. H. Chan School of Public Health
Tapeworms (cestodes) are flat, hermaphroditic worms that can live as parasites in the human gastrointestinal tract. Some of these organisms are primarily human pathogens, while others have animals as their natural hosts but can also cause human infection.
Taeniasis, diphyllobothriasis, hymenolepiasis, and dipylidiasis will be reviewed here. Ingestion of the eggs of Taenia solium causes cysticercosis, a tapeworm infection that is discussed separately. (See "Epidemiology, transmission, and prevention of cysticercosis" and "Clinical manifestations and diagnosis of cysticercosis" and "Treatment of cysticercosis".)
Adult tapeworms consist of a head, neck, and segmented body. The head (also known as a scolex) is equipped with suckers, hooks, or grooves (depending upon the species); the worm uses these to attach itself to the intestine of the host.
Each segment (known as a proglottid) has a complete set of reproductive organs. Depending on the species, the adult worm may have hundreds or thousands of proglottids. In some species (such as Taenia), the distal segments can separate from the rest of the body, and the proglottids (or the eggs they contain) are passed in the stool. In other species (such as Hymenolepis), proglottids degenerate within the host so only eggs are found in the stool.
Tapeworms are covered with a tegument through which they absorb nutrients and secrete waste. Different species of tapeworms can be differentiated by morphologic characteristics of the scolex, proglottids, and eggs .
- Schantz PM. Tapeworms (cestodiasis). Gastroenterol Clin North Am 1996; 25:637.
- Flisser A, Viniegra AE, Aguilar-Vega L, et al. Portrait of human tapeworms. J Parasitol 2004; 90:914.
- Eom KS. What is Asian Taenia? Parasitol Int 2006; 55 Suppl:S137.
- Hoberg EP. Phylogeny of Taenia: Species definitions and origins of human parasites. Parasitol Int 2006; 55 Suppl:S23.
- Thanchomnang T, Tantrawatpan C, Intapan PM, et al. Rapid molecular identification of human taeniid cestodes by pyrosequencing approach. PLoS One 2014; 9:e100611.
- Botero D, Tanowitz HB, Weiss LM, Wittner M. Taeniasis and cysticercosis. Infect Dis Clin North Am 1993; 7:683.
- Cicek AC, Sehitoglu I, Eksi S. Taenia infestation in the appendix: a case report. Southeast Asian J Trop Med Public Health 2013; 44:959.
- Emre A, Akbulut S, Bozdag Z, et al. Routine histopathologic examination of appendectomy specimens: retrospective analysis of 1255 patients. Int Surg 2013; 98:354.
- Schantz PM, Moore AC, Muñoz JL, et al. Neurocysticercosis in an Orthodox Jewish community in New York City. N Engl J Med 1992; 327:692.
- Craig P, Ito A. Intestinal cestodes. Curr Opin Infect Dis 2007; 20:524.
- Flisser A, Plancarte A, Correa D, et al. New approaches in the diagnosis of Taenia solium cysticercosis and taeniasis. Ann Parasitol Hum Comp 1990; 65 Suppl 1:95.
- Allan JC, Avila G, Garcia Noval J, et al. Immunodiagnosis of taeniasis by coproantigen detection. Parasitology 1990; 101 Pt 3:473.
- Maass M, Delgado E, Knobloch J. Detection of Taenia solium antigens in merthiolate-form preserved stool samples. Trop Med Parasitol 1991; 42:112.
- Chapman A, Vallejo V, Mossie KG, et al. Isolation and characterization of species-specific DNA probes from Taenia solium and Taenia saginata and their use in an egg detection assay. J Clin Microbiol 1995; 33:1283.
- Allan JC, Craig PS. Coproantigens in taeniasis and echinococcosis. Parasitol Int 2006; 55 Suppl:S75.
- Allan JC, Mencos F, Garcia-Noval J, et al. Dipstick dot ELISA for the detection of Taenia coproantigens in humans. Parasitology 1993; 107 ( Pt 1):79.
- Deplazes P, Eckert J, Pawlowski ZS, et al. An enzyme-linked immunosorbent assay for diagnostic detection of Taenia saginata copro-antigens in humans. Trans R Soc Trop Med Hyg 1991; 85:391.
- Bowles J, McManus DP. Genetic characterization of the Asian Taenia, a newly described taeniid cestode of humans. Am J Trop Med Hyg 1994; 50:33.
- Gasser RB, Chilton NB. Characterisation of taeniid cestode species by PCR-RFLP of ITS2 ribosomal DNA. Acta Trop 1995; 59:31.
- Sako Y, Nkouawa A, Yanagida T, Ito A. Loop-mediated isothermal amplification method for a differential identification of human Taenia tapeworms. Methods Mol Biol 2013; 1039:109.
- Nkouawa A, Sako Y, Li T, et al. A loop-mediated isothermal amplification method for a differential identification of Taenia tapeworms from human: application to a field survey. Parasitol Int 2012; 61:723.
- Praet N, Verweij JJ, Mwape KE, et al. Bayesian modelling to estimate the test characteristics of coprology, coproantigen ELISA and a novel real-time PCR for the diagnosis of taeniasis. Trop Med Int Health 2013; 18:608.
- Jeon HK, Chai JY, Kong Y, et al. Differential diagnosis of Taenia asiatica using multiplex PCR. Exp Parasitol 2009; 121:151.
- González LM, Montero E, Morakote N, et al. Differential diagnosis of Taenia saginata and Taenia saginata asiatica taeniasis through PCR. Diagn Microbiol Infect Dis 2004; 49:183.
- Yamasaki H, Allan JC, Sato MO, et al. DNA differential diagnosis of taeniasis and cysticercosis by multiplex PCR. J Clin Microbiol 2004; 42:548.
- Mayta H, Gilman RH, Prendergast E, et al. Nested PCR for specific diagnosis of Taenia solium taeniasis. J Clin Microbiol 2008; 46:286.
- Cabello FC. Salmon aquaculture and transmission of the fish tapeworm. Emerg Infect Dis 2007; 13:169.
- Nakaji K, Suzumura S, Nakae Y, et al. Effects in the control of edema of the papilla of Vater by epinephrine saline irrigation after endoscopic retrograde cholangiopancreatography in an endoscopy center in Japan, 2003 to 2007: exploratory retrospective analysis to evaluate the characteristics of eligible patients with a focus on serum amylase levels. Intern Med 2009; 48:945.
- de Marval F, Gottstein B, Weber M, Wicht B. Imported diphyllobothriasis in Switzerland: molecular methods to define a clinical case of Diphyllobothrium infection as Diphyllobothrium dendriticum, August 2010. Euro Surveill 2013; 18.
- Park SH, Eom KS, Park MS, et al. A case of Diphyllobothrium nihonkaiense infection as confirmed by mitochondrial COX1 gene sequence analysis. Korean J Parasitol 2013; 51:471.
- Park SC, Keum B, Jeen YT, Chun HJ. Diphyllobothrium latum accidentally detected by colonoscopy. Dig Liver Dis 2011; 43:664.
- Soga K, Sakagami J, Handa O, et al. Long fish tapeworm in the intestine: an in situ observation by capsule endoscopy. Intern Med 2011; 50:325.
- Flores EC, Plumb SC, McNeese MC. Intestinal parasitosis in an urban pediatric clinic population. Am J Dis Child 1983; 137:754.
- Muehlenbachs A, Bhatnagar J, Agudelo CA, et al. Malignant Transformation of Hymenolepis nana in a Human Host. N Engl J Med 2015; 373:1845.
- Steinmann P, Cringoli G, Bruschi F, et al. FLOTAC for the diagnosis of Hymenolepis spp. infection: proof-of-concept and comparing diagnostic accuracy with other methods. Parasitol Res 2012; 111:749.
- Barda B, Cajal P, Villagran E, et al. Mini-FLOTAC, Kato-Katz and McMaster: three methods, one goal; highlights from north Argentina. Parasit Vectors 2014; 7:271.
- Kim BJ, Song KS, Kong HH, et al. Heavy Hymenolepis nana infection possibly through organic foods: report of a case. Korean J Parasitol 2014; 52:85.
- Groll E. Praziquantel for cestode infections in man. Acta Trop 1980; 37:293.
- Ohnishi K, Sakamoto N, Kobayashi K, et al. Therapeutic effect of praziquantel against Taeniasis asiatica. Int J Infect Dis 2013; 17:e656.
- Drugs for Parasitic Infections, 3rd Ed, The Medical Letter, New Rochelle, NY 2013.
- Pawłowski ZS. Efficacy of low doses of praziquantel in taeniasis. Acta Trop 1990; 48:83.
- Brindley PJ, Sher A. Immunological involvement in the efficacy of praziquantel. Exp Parasitol 1990; 71:245.
- Frayha GJ, Smyth JD, Gobert JG, Savel J. The mechanisms of action of antiprotozoal and anthelmintic drugs in man. Gen Pharmacol 1997; 28:273.
- Juan JO, Lopez Chegne N, Gargala G, Favennec L. Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru. Trans R Soc Trop Med Hyg 2002; 96:193.
- Chero JC, Saito M, Bustos JA, et al. Hymenolepis nana infection: symptoms and response to nitazoxanide in field conditions. Trans R Soc Trop Med Hyg 2007; 101:203.