Interstitial lung disease in dermatomyositis and polymyositis: Clinical manifestations and diagnosis
- Paul F Dellaripa, MD
Paul F Dellaripa, MD
- Associate Professor of Medicine
- Harvard Medical School
- Marc L Miller, MD
Marc L Miller, MD
- Clinical Assistant Professor of Medicine
- Tufts University School of Medicine
- Section Editors
- Ira N Targoff, MD
Ira N Targoff, MD
- Section Editor — Muscle Disease
- Professor of Medicine, Section of Rheumatology
- University of Oklahoma Health Sciences Center
- Kevin R Flaherty, MD, MS
Kevin R Flaherty, MD, MS
- Section Editor — Interstitial Lung Disease
- Associate Professor of Medicine
- University of Michigan Health System
- Deputy Editors
- Helen Hollingsworth, MD
Helen Hollingsworth, MD
- Deputy Editor — Pulmonary, Critical Care, and Sleep Medicine
- Associate Professor of Medicine
- Boston University School of Medicine
- Monica Ramirez Curtis, MD, MPH
Monica Ramirez Curtis, MD, MPH
- Deputy Editor — Rheumatology
- Instructor of Medicine, Part-time
- Harvard Medical School
Dermatomyositis (DM) and polymyositis (PM) are classified as idiopathic inflammatory myopathies. Among patients with DM or PM, interstitial lung disease (ILD) is a major cause of morbidity and mortality. A general approach to the evaluation of ILD is provided separately. (See "Approach to the adult with interstitial lung disease: Clinical evaluation" and "Approach to the adult with interstitial lung disease: Diagnostic testing".)
In patients with DM or PM, ILD must be distinguished from other causes of pulmonary disease:
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- CLINICAL FEATURES
- Laboratory testing
- Pulmonary function tests
- Diagnosis of ILD in patients with DM or PM
- - Determining the type of ILD
- - Atypical or rapidly progressive ILD
- Diagnosis of DM or PM in patients with ILD
- DIFFERENTIAL DIAGNOSIS
- Heart failure
- Drug-induced pneumonitis
- Alveolar hemorrhage
- OTHER CAUSES OF DYSPNEA IN DM AND PM
- Spontaneous pneumomediastinum
- Respiratory muscle weakness
- Thromboembolic disease
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS