Medline ® Abstract for Reference 19
of 'Interferon-gamma release assays for diagnosis of latent tuberculosis infection'
19
TI
Use of an interferon-gamma based assay to assess bladder cancer patients treated with intravesical BCG and exposed to tuberculosis.
AU
Silverman MS, Reynolds D, Kavsak PA, Garay J, Daly A, Davis I
SO
Clin Biochem. 2007 Aug;40(12):913-5. Epub 2007 Apr 27.
OBJECTIVE:
Compare the QuantiFERON-TB Gold In-Tube (QFT) assay and the tuberculin skin test (TST) in bladder cancer patients receiving high dose BCG therapy (BCG patients).
DESIGN AND METHODS:
BCG patients and healthy visitors, both exposed to tuberculosis, were screened with a TST and QFT.
RESULTS:
QFT-TST correlation was excellent in visitors, but poor in BCG patients. BCG therapy predicted a positive TST (p<0.001) but not a positive QFT (p=0.35).
DISCUSSION:
The management of BCG patients was impacted, by measuring the QFT.
AD
University of Toronto, Ontario, Canada. msilverman@rogers.com
PMID