Intercurrent hepatobiliary disease during pregnancy
- Richard H Lee, MD
Richard H Lee, MD
- Assistant Professor of Clinical Obstetrics and Gynecology
- Division of Maternal Fetal Medicine
- Keck School of Medicine of the University of Southern California
- Tram T Tran, MD
Tram T Tran, MD
- Medical Director of Liver Transplantation
- Liver Disease and Transplant Center at Cedars-Sinai.
- Section Editors
- Keith D Lindor, MD
Keith D Lindor, MD
- Section Editor — Alcoholic and Metabolic Liver Disease
- Professor of Medicine, Mayo Clinic College of Medicine
- Dean, College of Health Solutions
- Arizona State University
- Charles J Lockwood, MD, MHCM
Charles J Lockwood, MD, MHCM
- Section Editor — Obstetrics
- Senior Vice President, USF Health
- Dean, Morsani College of Medicine
- Professor, Obstetrics and Gynecology
- University of South Florida
When liver disease is noted in a pregnant woman, there are three possible etiologic relationships. (See "Approach to liver disease occurring during pregnancy".)
●The patient has a liver disease induced by pregnancy. These include acute fatty liver of pregnancy, intrahepatic cholestasis of pregnancy, hyperemesis gravidarum, and preeclampsia or the HELLP syndrome. (See appropriate topic reviews.)
●The patient has preexisting chronic liver disease. (See "Pregnancy in women with pre-existing chronic liver disease".)
●The patient has developed a new liver disease during pregnancy.
This topic review will discuss the last issue. Viral hepatitis, for example, is probably the most common liver disease in pregnancy. However, some of these disorders, such as hepatitis E, can have a fulminant course in the pregnant woman. In addition, the physiologic changes associated with pregnancy may predispose to hepatobiliary diseases, particularly cholelithiasis.
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