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Initial treatment of mantle cell lymphoma

Arnold S Freedman, MD
Jonathan W Friedberg, MD
Section Editor
Andrew Lister, MD, FRCP, FRCPath, FRCR
Deputy Editor
Alan G Rosmarin, MD


Mantle cell lymphoma (MCL), one of the B cell non-Hodgkin lymphomas (NHLs), has a variable course. A minority of patients with this disorder may survive untreated for many years. However, in more patients, MCL assumes a more virulent character, akin to that of an aggressive NHL variant.

The initial treatment of MCL will be discussed here. Clinical and pathologic features, diagnosis, and differential diagnosis of this disorder are discussed separately, as is the treatment of relapsed or refractory MCL. (See "Clinical manifestations, pathologic features, and diagnosis of mantle cell lymphoma" and "Treatment of relapsed or refractory mantle cell lymphoma".)


Oncologic emergencies and treatment-related hematologic toxicities are common in the aggressive NHLs. Clinicians must always be alert to their potential presence, and be prepared to deal with them urgently and effectively. (See "Clinical presentation and diagnosis of non-Hodgkin lymphoma", section on 'Oncologic emergencies'.)

Emergencies that are more common in patients with MCL include hyperleukocytosis and intestinal obstruction or intussusception:

Involvement of the gastrointestinal tract is common in MCL, occasionally presenting with multiple intestinal polyposis and intestinal obstruction or intussusception. (See "Epidemiology, clinical features, and diagnosis of mechanical small bowel obstruction in adults" and "Clinical presentation and diagnosis of primary gastrointestinal lymphomas".)

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Literature review current through: Dec 2017. | This topic last updated: Oct 10, 2017.
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