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Initial treatment of advanced (stage III-IV) classical Hodgkin lymphoma

Authors
Steven Horwitz, MD
Joachim Yahalom, MD
Section Editor
Arnold S Freedman, MD
Deputy Editor
Alan G Rosmarin, MD

INTRODUCTION

Hodgkin lymphoma (HL, formerly called Hodgkin's disease) is a group of cancers characterized by malignant Reed-Sternberg cells in an appropriate reactive cellular background. HL tends to arise within lymph node areas and to spread in an orderly fashion to contiguous areas of lymph nodes [1]. Once the diagnosis of HL has been established, subsequent therapy is based upon the stage of the disease, as currently defined by the Cotswolds classification (table 1). (See "Staging and prognosis of Hodgkin lymphoma" and "Overview of the treatment of classical Hodgkin lymphoma in adults".)

In this discussion, advanced stage HL refers to clinical stage (CS) III and IV disease. CS III describes involvement of lymph nodes or lymphoid structures on both sides of the diaphragm. CS IV refers to diffuse or disseminated involvement of one or more extranodal organs or tissues, with or without lymph node disease. (See "Staging and prognosis of Hodgkin lymphoma".)

The initial treatment of advanced stage HL will be reviewed here. The following are discussed separately:

The evaluation of the patient before, during, and after therapy. (See "Monitoring of the patient with classical Hodgkin lymphoma during and after treatment" and "Long-term follow-up of the patient with classical Hodgkin lymphoma".)

The treatment of favorable early stage HL. (See "Treatment of favorable prognosis early (stage I-II) classical Hodgkin lymphoma".)

                                              

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Literature review current through: Nov 2016. | This topic last updated: Wed Oct 19 00:00:00 GMT 2016.
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