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Initial postoperative therapy for glioblastoma and anaplastic astrocytoma

Tracy Batchelor, MD, MPH
Section Editors
Jay S Loeffler, MD
Patrick Y Wen, MD
Deputy Editor
April F Eichler, MD, MPH


High-grade gliomas are malignant, rapidly progressive brain tumors that are divided into anaplastic glioma (anaplastic astrocytoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma) and glioblastoma based upon their histopathologic features [1]. (See "Classification and pathologic diagnosis of gliomas", section on 'Histopathologic and molecular classification'.)

Most high-grade gliomas are best managed with a combined modality approach, incorporating adjuvant postoperative radiation therapy and adjuvant chemotherapy following initial surgery. Postoperative chemotherapy is discussed in this topic.

Other topics that are covered separately include:

The diagnostic approach to patients with suspected brain tumors (see "Overview of the clinical features and diagnosis of brain tumors in adults")

Initial surgical management of malignant gliomas (see "Clinical presentation, initial surgical approach, and prognosis of high-grade gliomas")

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Literature review current through: Nov 2017. | This topic last updated: Oct 03, 2017.
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