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Initial management of malignant pleural mesothelioma

Authors
Harvey I Pass, MD
Anne S Tsao, MD
Kenneth Rosenzweig, MD
Section Editors
Rogerio C Lilenbaum, MD, FACP
Joseph S Friedberg, MD
James R Jett, MD
Steven E Schild, MD
Deputy Editor
Sadhna R Vora, MD

INTRODUCTION

Malignant pleural mesothelioma (MPM) is a rare neoplasm that typically arises from the mesothelial surfaces of the pleural cavity. Mesotheliomas may also arise from the peritoneal surface, the tunica vaginalis, or pericardium.

MPM has a poor prognosis. The median survival of patients is between 6 and 18 months, and the outlook has not been substantially improved by newer therapeutic interventions. However, carefully selected patients with localized disease who receive aggressive multimodality therapy have relatively prolonged survival.

Data supporting current treatment recommendations are derived from observational studies. The benefits of incorporating surgery and radiation therapy (RT) into the initial treatment have not been demonstrated in randomized trials.

The initial management of patients with MPM is reviewed here. Other related topics include:

(See "Systemic treatment for unresectable malignant pleural mesothelioma".)

                      

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Literature review current through: Nov 2016. | This topic last updated: Thu Sep 22 00:00:00 GMT+00:00 2016.
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