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Inherited thrombophilias in pregnancy

Charles J Lockwood, MD, MHCM
Kenneth A Bauer, MD
Section Editors
Lawrence LK Leung, MD
Vincenzo Berghella, MD
Deputy Editor
Vanessa A Barss, MD, FACOG


Inherited thrombophilias are genetic conditions that increase the risk of thromboembolic disease. During pregnancy, the thrombogenic potential of these inherited disorders is enhanced because of the hypercoagulable state produced by normal pregnancy-associated physiologic changes in several coagulation factors [1-3]:

Resistance to activated protein C increases in the second and third trimesters

Protein S activity decreases due to reductions in total and free protein S antigen

Fibrinogen and factors II, VII, VIII, and X increase

Levels and activity of the fibrinolytic inhibitors, thrombin activatable fibrinolytic inhibitor (TAFI), plasminogen activator inhibitor type 1 (PAI-1) and PAI-2 increase

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Literature review current through: Oct 2017. | This topic last updated: Aug 04, 2017.
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