Medline ® Abstract for Reference 7
of 'Inherited susceptibility to melanoma'
Familial atypical multiple mole-melanoma syndrome.
Lynch HT, Frichot BC 3rd, Lynch JF
J Med Genet. 1978;15(5):352.
A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.