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Medline ® Abstract for Reference 106

of 'Inherited susceptibility to melanoma'

106
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Unaffected family members report improvements in daily routine sun protection 2 years following melanoma genetic testing.
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Aspinwall LG, Taber JM, Kohlmann W, Leaf SL, Leachman SA
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Genet Med. 2014 Nov;16(11):846-53. Epub 2014 Apr 24.
 
PURPOSE: Reducing ultraviolet radiation exposure may decrease melanoma risk in the hereditary melanoma setting. It is unknown whether genetic counseling and test reporting of CDKN2A/p16 mutation status promote long-term compliance with photoprotection recommendations, especially in unaffected mutation carriers.
METHODS: This study evaluated changes 2 years following melanoma genetic testing in self-reported practice of sun protection (sunscreen, photoprotective clothing, and ultraviolet radiation avoidance) among 37 members of two CDKN2A/p16 kindreds (10 unaffected carriers, 11 affected carriers, and 16 unaffected noncarriers; response rate = 64.9% of eligible participants).
RESULTS: Multivariate profile analysis indicated that all three participant groups reported increased daily routine practice of sun protection 2 years following melanoma genetic testing (P<0.02), with 96.9% reporting that at least one sun protection behavior was part of their daily routine, up from 78.1% at baseline (P<0.015). Unaffected carriers (P<0.024) and unaffected noncarriers (P<0.027) reported significantly more frequent use of photoprotective clothing. Affected carriers maintained adherence to all sun protection behaviors. Reported sunburns in the past 6 months decreased significantly (P<0.018).
CONCLUSION: Members of high-risk families reported increased daily routine sun protection and decreased sunburns 2 years following melanoma genetic testing, with no net decline in sun protection following negative test results. Thus, genetic testing and counseling may motivate sustained improvements in prevention behaviors.
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Department of Psychology, University of Utah, Salt Lake City, Utah, USA.
PMID