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Medline ® Abstract for Reference 103

of 'Inherited susceptibility to melanoma'

Patterns of photoprotection following CDKN2A/p16 genetic test reporting and counseling.
Aspinwall LG, Leaf SL, Kohlmann W, Dola ER, Leachman SA
J Am Acad Dermatol. 2009;60(5):745.
BACKGROUND: The impact of melanoma genetic testing and counseling on photoprotective behaviors is unknown.
OBJECTIVE: To determine if genetic testing and counseling alter compliance with photoprotection recommendations.
METHODS: Reported use of sunscreen, protective clothing, and sun avoidance by 59 members of CDKN2A/p16-mutation positive pedigrees was assessed as a function of mutation status and melanoma history, before, immediately after, and 1 month following test reporting.
RESULTS: Intentions to practice all photoprotective behaviors increased in all participant groups (P<.0001). At 1 month, 33% of participants reported the adoption of a new photoprotective behavior. Subpopulation analyses identified different patterns of change in photoprotection relative to baseline (P<.005), with no net decline in any group.
LIMITATIONS: This initial study of CDKN2A/p16 families is small and awaits replication in a larger sample.
CONCLUSION: Melanoma genetic testing and counseling enhanced intentions to implement photoprotective strategies and did not result in reduced compliance in the CDKN2A/p16-subpopulation.
Department of Psychology, University of Utah, Salt Lake City, Utah, USA.