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Medline ® Abstract for Reference 65

of 'Infusion reactions to systemic chemotherapy'

65
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Successful administration of carboplatin in patients with clinically documented carboplatin hypersensitivity.
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Rose PG, Fusco N, Smrekar M, Mossbruger K, Rodriguez M
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Gynecol Oncol. 2003;89(3):429.
 
OBJECTIVE: The goal of this study was to evaluate the tolerance and effectiveness of carboplatin rechallenge using a prolonged desensitizing carboplatin infusion regimen in patients with clinically documented moderate-severe carboplatin hypersensitivity.
METHOD: Patients admitted for carboplatin infusion were identified by computerized pharmacy records and retrospectively analyzed.
RESULT: Thirty-three patients with recurrent ovarian (N = 27), peritoneal (N = 4), tubal (N = 1), and cervical (N = 1) cancer treated with a prolonged desensitizing carboplatin infusion regimen were identified. The patients had received a median of 10 courses of carboplatin (range 3-33) before developing the moderate-severe hypersensitivity reaction. Two hundred and fifteen courses (median 5, range 1-52) were administered. Twenty-nine patients (88%) were successfully rechallenged while four had a recurrent moderate-severe carboplatin hypersensitivity precluding further administration. Despite initial tolerance of the infusion schedule moderate-severe carboplatin hypersensitivity recurred in 3 additional patients (9%) after two, three, and six subsequent courses. Objective responses to therapy were seen in 22 of 28 evaluable patients (79%).
CONCLUSIONS: A prolonged desensitizing carboplatin infusion regimen is tolerated in the majority of patients with clinically documented moderate-severe carboplatin hypersensitivity. Objective response rates seem acceptable with this schedule.
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Case Western Reserve University, Ireland Cancer Center, Cleveland, OH 44106, USA. prose@metrohealth.org
PMID