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Medline ® Abstract for Reference 21

of 'Infusion reactions to systemic chemotherapy'

Oxaliplatin induces a delayed immune-mediated hemolytic anemia: a case report and review of the literature.
Noronha V, Burtness B, Murren J, Duffy TP
Clin Colorectal Cancer. 2005;5(4):283.
We report a case of a 59-year-old woman with metastatic carcinoma of the ileocecal region who received FOLFOX(oxaliplatin/leucovorin/5-fluorouracil) and bevacizumab therapy and exhibited a partial remission with minimal side effects. She developed a mild self-limited episode of immune-mediated hemolytic anemia during her 16th cycle of chemotherapy, which precluded her from receiving further oxaliplatin. We review the literature on oxaliplatin-induced immune-mediated hemolysis, including its mechanism, presenting symptoms, laboratory features, management, and implications for future therapy.
Mid Valley Oncology/Hematology, P.C., 407 Gidney Avenue, Newburgh, NY 12550, USA. vanita.noronha@gmail.com