Medline ® Abstract for Reference 204
of 'Infusion reactions to systemic chemotherapy'
Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide.
Khaw SL, Downie PA, Waters KD, Ashley DM, Heath JA
Pediatr Blood Cancer. 2007;49(3):341.
Mesna is widely used for the prevention of cyclophosphamide-related hemorrhagic cystitis. It has been associated with hypersensitivity-like cutaneous and systemic reactions in adult patients. We report a series of children with malignant disease, who developed such reactions following mesna administration and discuss possible mechanisms and management issues.
Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.