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Medline ® Abstract for Reference 124

of 'Infusion reactions to systemic chemotherapy'

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Abraxane for the treatment of gynecologic cancer patients with severe hypersensitivity reactions to paclitaxel.
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Fader AN, Rose PG
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Int J Gynecol Cancer. 2009;19(7):1281.
 
BACKGROUND: Paclitaxel is used in the treatment of most gynecologic malignancies. It is solubilized in Cremophor EL, a polyoxyethylated castor oil agent responsible for the high rate of paclitaxel-associated hypersensitivity reactions. Abraxane, a newer, Cremophor-free form of albumin bound paclitaxel has demonstrated an activity and an improved toxicity profile in breast and lung cancers.
CASE REPORTS: Five patients with gynecologic cancers (2 ovarian, 2 endometrial, and 1 cervical malignancy) received Abraxane after having a hypersensitivity reaction to paclitaxel. All five patients tolerated Abraxane well, experiencing no reactions or major side effects to the drug.
DISCUSSION: Abraxane is well tolerated in women with gynecologic cancer who have experienced a paclitaxel-associated hypersensitivity reaction. Further studies are ongoing to determine the clinical activity of Abraxane in the treatment of these malignancies.
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Department of Gynecology and Obstetrics, The Cleveland Clinic, Cleveland, OH 44195, USA. amanditan@yahoo.com
PMID