Hypersensitivity to procarbazine associated with angioedema, urticaria, and low serum complement activity

J Allergy Clin Immunol. 1976 Feb;57(2):134-40. doi: 10.1016/0091-6749(76)90032-4.

Abstract

Hypersensitivity to procarbazine associated with urticaria, angioedema, and painful joint swelling was found in a 20-year-old student being treated for Hodgkin's disease. A marked fall in complement component activity occurred simultaneously with the development of symtoms. It is suggested that generation of products of complement component activation could be important in the pathogenesis of hypersensitivity to some drugs.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angioedema / complications*
  • Complement C1 / deficiency
  • Complement C2 / deficiency
  • Complement C4 / deficiency
  • Complement System Proteins / deficiency*
  • Drug Hypersensitivity / complications*
  • Hodgkin Disease / drug therapy
  • Humans
  • Male
  • Procarbazine / adverse effects*
  • Procarbazine / therapeutic use
  • Urticaria / complications*

Substances

  • Complement C1
  • Complement C2
  • Complement C4
  • Procarbazine
  • Complement System Proteins