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Medline ® Abstract for Reference 74

of 'Induction therapy for acute myeloid leukemia in younger adults'

Prognostic factors of treatment outcomes in patients with granulocytic sarcoma.
Lan TY, Lin DT, Tien HF, Yang RS, Chen CY, Wu K
Acta Haematol. 2009;122(4):238.
PURPOSE: To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS).
METHODS: We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation.
RESULTS: The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028).
CONCLUSION: Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes.
Department of Orthopedics, National Taiwan University and Hospital, Taipei, Taiwan, ROC.