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Impaired sensitivity to thyroid hormone

Samuel Refetoff, MD
Alexandra M Dumitrescu, MD, PhD
Roy E Weiss, MD, PhD
Section Editors
David S Cooper, MD
Douglas S Ross, MD
Deputy Editor
Alison G Hoppin, MD


Impaired sensitivity to thyroid hormone (previously known as reduced sensitivity to thyroid hormone) describes any process that interferes with the effectiveness of thyroid hormone and includes defects in thyroid hormone action, transport, or metabolism [1-4].

The most common category is resistance to thyroid hormone (RTH), a syndrome characterized by reduced intracellular action of T3, the active thyroid hormone. RTH was first identified in 1967 as a syndrome of reduced end-organ responsiveness to thyroid hormone [5] and was subsequently associated with mutations in the gene encoding the beta form of the thyroid hormone receptor (TR-beta) [1,6,7].

Impaired sensitivity to thyroid hormone can be grouped according to the underlying mechanism, as follows (table 1) [8]:

Thyroid hormone cell membrane transport defect (THCMTD)

Thyroid hormone metabolism defect (THMD)


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Literature review current through: Sep 2016. | This topic last updated: Jul 7, 2015.
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