Medline ® Abstract for Reference 99
of 'Immune reconstitution inflammatory syndrome'
99
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Immune reconstitution syndrome after successful treatment of Pneumocystis carinii pneumonia in a man with human immunodeficiency virus type 1 infection.
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Koval CE, Gigliotti F, Nevins D, Demeter LM
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Clin Infect Dis. 2002;35(4):491.
We describe a 34-year-old man with human immunodeficiency virus infection who received successful treatment of minimally symptomatic Pneumocystis carinii pneumonia and who subsequently developed diffuse pulmonary infiltrates and hypoxia 2 weeks after initiation of combination antiretroviral therapy. Initial pathologic evaluation of lung-tissue samples revealed no organisms, but a polymerase chain reaction assay was strongly positive for P. carinii DNA. We hypothesize that this patient's clinical presentation denotes immune reconstitution syndrome in response to residual P. carinii antigen in the lung.
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Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. christine_koval@urmc.rochester.edu
PMID