Medline ® Abstract for Reference 114
of 'Immune reconstitution inflammatory syndrome'
114
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Sarcoid-like pulmonary disorder in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
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Naccache JM, Antoine M, Wislez M, Fleury-Feith J, Oksenhendler E, Mayaud C, Cadranel J
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Am J Respir Crit Care Med. 1999;159(6):2009.
We report two cases of HIV-infected patients who presented with diffuse interstitial micronodular lesions on chest X-ray after institution of protease inhibitor-containing highly active antiretroviral therapy (HAART). Granulomatous pulmonary disorder mimicking sarcoidosis was diagnosed on histopathological studies revealing noncaseating granuloma and bronchoalveolar lavage analysis showing an intense CD4(+) lymphocyte alveolitis. Causative agents such as infectious organisms and environmental compounds were excluded. The relationship between sarcoid-like reaction and immune reconstitution under HAART is discussed.
AD
Services de Pneumologie et de Réanimation Respiratoire, d'Anatomie-Pathologique, et d'Histologie Biologie Tumorale, Hôpital Tenon, Paris, France.
PMID