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Medline ® Abstract for Reference 56

of 'Immediate hypersensitivity reactions to radiocontrast media: Prevention of recurrent reactions'

The efficacy of single premedication with antihistamines for radiocontrast media hypersensitivity.
Lee SH, Park HW, Cho SH, Kim SS
Asia Pac Allergy. 2016;6(3):164. Epub 2016 Jul 28.
BACKGROUND: Single premedication with antihistamines for radiocontrast media (RCM) hypersensitivity is frequently used in real world at the emergent situation although its efficacy is not proven.
OBJECTIVE: To evaluate the effect of intravenous antihistamines as a premedication in general population who had experience of mild adverse reactions to iodinated RCM.
METHODS: A retrospective observational study on 14,785 subjects who had RCM-enhanced computed tomography scans between January 2014 and December 2015 in Seoul National University Hospital Gangnam Healthcare Center, Seoul, South Korea.
RESULTS: Among 453 subjects who had a history of mild RCM-induced hypersensitivity reactions, 273 subjects had a single premedication of intravenous antihistamine. When comparing antihistamine-premedication group and nonpremedication group, there is no protective effect ofantihistamines on the incidence rate and severity of hypersensitivity (10.6% vs. 11.7%, p = 0.729).
CONCLUSION: The clinical efficacy of a single premedication of antihistamines for mild RCM-induced hypersensitivity was not confirmed.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.; Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul 06236, Korea.