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Detection rate and false positive rate for Down syndrome screening tests - First and Second Trimester Evaluation of Risk Trial (FASTER) and Serum, Urine and Ultrasound Screening Study (SURUSS)
Test FASTER* SURUSS
Detection rate, percent FPR, percent Detection rate, percent FPR, percent Procedure related losses per 100,000 women screened
Integrated 85 0.8 85 0.9 6
95 5.0 90 2.1 15
Serum integrated 85 4.4 85 3.9 28
95 17 90 7.4 53
Combined 85 4.8 85 4.3 35
95 21 90 8.4 60
Quadruple 85 7.3 85 6.2 45
95 22 90 10.6 76
Triple 85 14 85 9.3 67
95 32 90 14.7 106
FPR: false positive rate.
* For FASTER, the first trimester combined test or first trimester component of the integrated test was done at 12 completed weeks of gestation.
For SURUSS, the first trimester combined test or first trimester component of the integrated test was done at 11 completed weeks of gestation.
Adapted from: Wald NJ, Rodeck C, Hackshaw AK, et al. Health Technol Assess 2003; 7:1.
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