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Disorders associated with acquired von Willebrand disease
Malignant diseases
Monoclonal gammopathy of undetermined significance
Multiple myeloma
Non-Hodgkin lymphoma
Chronic lymphocytic leukemia
Waldenström macroglobulinemia
Essential thrombocythemia
Polycythemia vera
Chronic myeloid leukemia
Wilms tumor
Other carcinomas
Immunologic disorders
Systemic lupus erythematosus
Other autoimmune diseases
States of high vascular flow
Ventricular septal defect
Aortic stenosis
Mitral valve prolapse
Ventricular assist device
Other disorders
Hypothyroidism
Gastrointestinal angiodyplasia
Uremia
Hemoglobinopathies
Drugs and other agents
Valproic acid
Hydroxyethyl starch
Antibiotics: griseofulvin, ciprofloxacin
The table includes a disorder only if there were three or more reports in the literature on its association with acquired von Willebrand disease.
Adapted from: Veyradier A, Jenkins CS, Fressinaud E, et al. Acquired von Willebrand syndrome: from pathophysiology to management. Thromb Haemost 2000; 84:175 and Federici AB, Rand JH, Bucciarelli P, et al. Acquired von Willebrand syndrome: data from an international registry. Thromb Haemost 2000; 84:346.
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