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IgG subclass deficiency

Author
Alan P Knutsen, MD
Section Editor
E Richard Stiehm, MD
Deputy Editor
Anna M Feldweg, MD

INTRODUCTION

The clinical presentation, pathogenesis, diagnosis, and treatment of immunoglobulin G (IgG) subclass deficiency are presented here. The physical and biologic properties of IgG subclasses are reviewed separately. (See "IgG subclasses: Physical properties, genetics, and biologic functions".)

DEFINITIONS

The term "IgG subclass deficiency" refers to a significant decrease in the serum concentrations of one or more subclasses of IgG in a patient whose total IgG concentration is normal [1].

Clinically significant deficiency — IgG subclass deficiency is a laboratory finding that does not necessarily equate to a clinical disorder. The diagnosis of a clinically significant IgG subclass deficiency requires evidence of antibody dysfunction in the form of recurrent infections and an inadequate response to vaccine challenge.

Lower limits of normal — Normal ranges of IgG and IgG subclasses in healthy populations are defined as mean levels ±2 standard deviations, which include 95 percent of individuals. The remaining 5 percent have levels 2.5 percent below or 2.5 percent above this range. The normal ranges for IgG subclasses are broad and vary with the age of the population studied, presence or absence of disease, and the method of analysis (table 1) [2-9]. The data in the table may be summarized further for simplicity.

For children 4 to 10 years of age, levels below the following are considered abnormal:

                               

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Literature review current through: Nov 2016. | This topic last updated: Wed Nov 16 00:00:00 GMT+00:00 2016.
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