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Hypertrophic cardiomyopathy: Management of concurrent atrial fibrillation

Martin S Maron, MD
Section Editors
Samuel Lévy, MD
William J McKenna, MD
Deputy Editor
Brian C Downey, MD, FACC


Hypertrophic cardiomyopathy (HCM) is a genetically determined heart muscle disease most often (60 to 70 percent) caused by mutations in one of several sarcomere genes that encode components of the contractile apparatus. (See "Hypertrophic cardiomyopathy: Gene mutations and clinical genetic testing".)

HCM is characterized by left ventricular hypertrophy (LVH) of various morphologies, with a wide array of clinical manifestations and hemodynamic abnormalities (figure 1). Depending in part upon the site and extent of cardiac hypertrophy, HCM patients can develop one or more of the following abnormalities:

LV outflow obstruction (see "Hypertrophic cardiomyopathy: Morphologic variants and the pathophysiology of left ventricular outflow tract obstruction")

Diastolic dysfunction

Myocardial ischemia


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Literature review current through: Jan 2017. | This topic last updated: Wed Aug 31 00:00:00 GMT+00:00 2016.
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