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Hypersensitivity reactions to clopidogrel

Authors
John R Cohn, MD
Michael P Savage, MD
Section Editors
N Franklin Adkinson, Jr, MD
Donald Cutlip, MD
Deputy Editor
Anna M Feldweg, MD

INTRODUCTION

Clopidogrel is a thienopyridine drug that inhibits platelet aggregation by blocking the adenosine diphosphate P2Y12 receptor. The most frequent use of clopidogrel is to prevent potentially fatal thrombosis of newly implanted coronary stents. Accordingly, hypersensitivity reactions to clopidogrel have particular importance in this setting, since the timing typically coincides with the period of heightened vulnerability for stent thrombosis. The most common hypersensitivity reactions to clopidogrel are dermatologic eruptions, although severe systemic reactions can also occur.

The incidence and clinical manifestations of clopidogrel reactions are discussed here. Management options for dermatologic eruptions are also reviewed. Therapeutic use of clopidogrel in the management of atherosclerotic arterial disease is reviewed separately:

(See "Antiplatelet agents in acute non-ST elevation acute coronary syndromes".)

(See "Antiplatelet therapy for secondary prevention of stroke".)

(See "Antiplatelet agents in acute ST elevation myocardial infarction".)

                           

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Literature review current through: Nov 2016. | This topic last updated: Mon Jan 25 00:00:00 GMT+00:00 2016.
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