Medline ® Abstract for Reference 36
of 'Hyperimmunoglobulin D syndrome: Pathophysiology'
Decreased cholesterol levels reflect a consumption of anti-inflammatory isoprenoids associated with an impaired control of inflammation in a mouse model of mevalonate kinase deficiency.
Marcuzzi A, Decorti G, Pontillo A, Ventura A, Tommasini A
Inflamm Res. 2010 May;59(5):335-8. Epub 2010 Feb 21.
OBJECTIVE: The aim of this study was to evaluate, in a mouse model of mevalonate kinase deficiency (MKD), the possible link between inflammatory symptoms and serum cholesterol levels.
MATERIALS AND METHODS: Balb/c mice were treated with alendronate and bacterial muramyl dipeptide. Body temperature, interleukin-1 beta (IL-1 beta) secretion and serum cholesterol levels were measured.
RESULTS: An increased production of the pro-inflammatory cytokine IL-1 beta (p<0.05) and a rise in body temperature (p<0.05) was observed, while, in parallel, serum cholesterol concentration significantly decreased (p<0.05). These effects were completely reversed when animals were treated with exogenous isoprenoids.
CONCLUSIONS: In the mouse model of MKD, the inflammatory response is associated with a reduction in cholesterol levels, and hence this parameter could be used as an indicator of isoprenoid consumption. In addition, plant derived isoprenoids could represent candidate treatments for this disease.
Paediatric Division, Institute of Child Health, IRCCS Burlo Garofolo, via dell'Istria 65/1, 34137, Trieste, Italy. firstname.lastname@example.org