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Hypereosinophilic syndromes: Treatment

Florence Roufosse, MD
Amy D Klion, MD
Peter F Weller, MD, MACP
Section Editor
Bruce S Bochner, MD
Deputy Editors
Anna M Feldweg, MD
Alan G Rosmarin, MD


The hypereosinophilic syndromes (HES) are a group of rare disorders marked by the sustained overproduction of eosinophils, in which eosinophilic infiltration and mediator release cause damage to multiple organs. The urgency of treatment and choice of therapy is based upon the patient's presentation, as well as laboratory findings and the results of mutational analysis.

The treatment and prognosis of HES will be reviewed here. The clinical features, pathophysiology, evaluation, and diagnosis of HES are discussed separately. (See "Hypereosinophilic syndromes: Clinical manifestations, pathophysiology, and diagnosis".)


Some patients with HES require immediate treatment, while others can be safely monitored.

Goals of therapy — The overall goals of therapy are reduction of the absolute eosinophil count (AEC), amelioration of signs and symptoms, and prevention of disease progression [1].

Timing — The urgency with which patients are treated depends upon the severity of hypereosinophilia (HE) and the presence of signs and symptoms of the disease [2]:

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Literature review current through: Dec 2017. | This topic last updated: Jan 04, 2018.
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