Hydrocephalus in children: Physiology, pathogenesis, and etiology
- Abilash Haridas, MD
Abilash Haridas, MD
- Pediatric & Cerebrovascular Neurosurgery, Children’s Hospital of Michigan
- Assistant Professor of Neurosurgery, Wayne State University
- Tadanori Tomita, MD
Tadanori Tomita, MD
- Yeager Professor and Division Head of Pediatric Neurosurgery,
- Director, Falk Brain Tumor Center
- Ann & Robert H. Lurie Children’s Hospital of Chicago;
- Professor and Vice-Chair, Department of Neurosurgery,
- Northwestern University Feinberg School of Medicine
Hydrocephalus is a disorder in which an excessive amount of cerebrospinal fluid (CSF) accumulates within the cerebral ventricles and/or subarachnoid spaces, resulting in ventricular dilation and increased intracranial pressure (ICP) [1,2].
The physiology, pathogenesis, and etiology of hydrocephalus will be reviewed here. The clinical features, diagnosis, management, and prognosis of hydrocephalus are discussed separately. (See "Hydrocephalus in children: Clinical features and diagnosis" and "Hydrocephalus in children: Management and prognosis".)
Normal pressure hydrocephalus, a condition seen predominantly in adults in which the cerebral ventricles are pathologically enlarged, but the ICP is not elevated, is also discussed separately. (See "Normal pressure hydrocephalus".)
The following terms are used this topic:
●Obstructive hydrocephalus – Obstructive hydrocephalus (also called noncommunicating hydrocephalus) refers to excess accumulation of cerebrospinal fluid (CSF) due to structural blockage of CSF flow within the ventricular system. This is the most common form of hydrocephalus in children and is almost always associated with increased intracranial pressure (ICP). (See 'Obstruction' below.)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- CSF production
- CSF circulation
- CSF absorption
- Impaired absorption
- Excessive production
- - Neural tube defects
- - Isolated hydrocephalus
- - X-linked hydrocephalus
- - CNS malformations
- - Syndromic forms
- - Intrauterine infection
- - Choroid plexus papilloma or carcinoma
- Acquired hydrocephalus
- - Posthemorrhagic hydrocephalus
- - CNS tumors
- - CNS infections
- Low pressure hydrocephalus
- INFORMATION FOR PATIENTS