Hookworm-related cutaneous larva migrans
- Peter F Weller, MD, MACP
Peter F Weller, MD, MACP
- Editor-in-Chief — Infectious Diseases
- Section Editor — Tropical Medicine
- William Bosworth Castle Professor of Medicine
- Harvard Medical School
- Professor of Immunology and Infectious Diseases
- Harvard T. H. Chan School of Public Health
- Karin Leder, MBBS, FRACP, PhD, MPH, DTMH
Karin Leder, MBBS, FRACP, PhD, MPH, DTMH
- Section Editor — Travel Medicine
- Head of Infectious Diseases Unit
- Monash University, Australia
Cutaneous larva migrans (CLM) is a clinical syndrome consisting of an erythematous migrating linear or serpiginous cutaneous track; an alternative term is creeping eruption.
It most frequently occurs as a result of human infection with the larvae of the dog or cat hookworms, Ancylostoma braziliense or Ancylostoma caninum; it also may be caused by larvae of other animal parasites that are not natural human parasites .
CLM caused by an animal hookworm is commonly referred to as hookworm-related cutaneous larva migrans (HrCLM) .
Issues related to CLM caused by human infection with larvae of dog or cat hookworms will be reviewed here. Issues related to human hookworm infection (caused by Ancylostoma duodenale or Necator americanus) are discussed separately. (See "Hookworm infection".)
The hookworms responsible for cutaneous larva migrans (CLM) are distributed worldwide; infection is more frequent in warmer climates, especially in the tropical and subtropical countries of Southeast Asia, Africa, South America, Caribbean, and the southeastern parts of the United States. Larvae are found on sandy beaches, in sand boxes, and under dwellings.To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
- Monsel G, Caumes E. Recent developments in dermatological syndromes in returning travelers. Curr Opin Infect Dis 2008; 21:495.
- Le Joncour A, Lacour SA, Lecso G, et al. Molecular characterization of Ancylostoma braziliense larvae in a patient with hookworm-related cutaneous larva migrans. Am J Trop Med Hyg 2012; 86:843.
- Sherman SC, Radford N. Severe infestation of cutaneous larva migrans. J Emerg Med 2004; 26:347.
- Centers for Disease Control and Prevention (CDC). Outbreak of cutaneous larva migrans at a children's camp--Miami, Florida, 2006. MMWR Morb Mortal Wkly Rep 2007; 56:1285.
- Gillespie SH. Cutaneous Larva Migrans. Curr Infect Dis Rep 2004; 6:50.
- Lederman ER, Weld LH, Elyazar IR, et al. Dermatologic conditions of the ill returned traveler: an analysis from the GeoSentinel Surveillance Network. Int J Infect Dis 2008; 12:593.
- Blackwell V, Vega-Lopez F. Cutaneous larva migrans: clinical features and management of 44 cases presenting in the returning traveller. Br J Dermatol 2001; 145:434.
- Kincaid L, Klowak M, Klowak S, Boggild AK. Management of imported cutaneous larva migrans: A case series and mini-review. Travel Med Infect Dis 2015; 13:382.
- Ma DL, Vano-Galvan S. IMAGES IN CLINICAL MEDICINE. Creeping Eruption--Cutaneous Larva Migrans. N Engl J Med 2016; 374:e16.
- Tan SK, Liu TT. Cutaneous larva migrans complicated by Löffler syndrome. Arch Dermatol 2010; 146:210.
- Hochedez P, Caumes E. Hookworm-related cutaneous larva migrans. J Travel Med 2007; 14:326.
- Jelinek T, Maiwald H, Nothdurft HD, Löscher T. Cutaneous larva migrans in travelers: synopsis of histories, symptoms, and treatment of 98 patients. Clin Infect Dis 1994; 19:1062.
- Caumes E, Danis M. From creeping eruption to hookworm-related cutaneous larva migrans. Lancet Infect Dis 2004; 4:659.
- Hochedez P, Caumes E. Common skin infections in travelers. J Travel Med 2008; 15:252.
- Heukelbach J, Feldmeier H. Epidemiological and clinical characteristics of hookworm-related cutaneous larva migrans. Lancet Infect Dis 2008; 8:302.
- Archer M. Late presentation of cutaneous larva migrans: a case report. Cases J 2009; 2:7553.
- Siriez JY, Angoulvant F, Buffet P, et al. Individual variability of the cutaneous larva migrans (CLM) incubation period. Pediatr Dermatol 2010; 27:211.
- Yap FB. Cutaneous larva migrans in Hospital Kuala Lumpur, Malaysia: rate of correct diagnosis made by the referring primary care doctors. Trans R Soc Trop Med Hyg 2011; 105:405.
- Jackson A, Heukelbach J, Calheiros CM, et al. A study in a community in Brazil in which cutaneous larva migrans is endemic. Clin Infect Dis 2006; 43:e13.
- Opie KM, Heenan PJ, Delaney TA, Rohr JB. Two cases of eosinophilic pustular folliculitis associated with parasitic infestations. Australas J Dermatol 2003; 44:217.
- Caumes E, Ly F, Bricaire F. Cutaneous larva migrans with folliculitis: report of seven cases and review of the literature. Br J Dermatol 2002; 146:314.
- Feldmeier H, Schuster A. Mini review: Hookworm-related cutaneous larva migrans. Eur J Clin Microbiol Infect Dis 2012; 31:915.
- Rivera-Roig V, Sánchez JL, Hillyer GV. Hookworm folliculitis. Int J Dermatol 2008; 47:246.
- Prickett KA, Ferringer TC. What's eating you? Cutaneous larva migrans. Cutis 2015; 95:126.
- Drugs for Parasitic Infections, 3rd Ed, The Medical Letter, New Rochelle, NY 2013.
- Albanese G, Venturi C, Galbiati G. Treatment of larva migrans cutanea (creeping eruption): a comparison between albendazole and traditional therapy. Int J Dermatol 2001; 40:67.
- Schuster A, Lesshafft H, Reichert F, et al. Hookworm-related cutaneous larva migrans in northern Brazil: resolution of clinical pathology after a single dose of ivermectin. Clin Infect Dis 2013; 57:1155.
- Monsel G, Caumes E. What's New in Travel-Associated Dermatology? J Travel Med 2015; 22:221.
- Vanhaecke C, Perignon A, Monsel G, et al. The efficacy of single dose ivermectin in the treatment of hookworm related cutaneous larva migrans varies depending on the clinical presentation. J Eur Acad Dermatol Venereol 2014; 28:655.
- Veraldi S, Rizzitelli G. Effectiveness of a new therapeutic regimen with albendazole in cutaneous larva migrans. Eur J Dermatol 1999; 9:352.
- Caumes E. Efficacy of albendazole ointment on cutaneous larva migrans in 2 young children. Clin Infect Dis 2004; 38:1647.
- MUHLEISEN JP. Demonstration of pulmonary migration of the causative organism of creeping eruption. Ann Intern Med 1953; 38:595.
- Del Giudice P, Desalvador F, Bernard E, et al. Loeffler's syndrome and cutaneous larva migrans: a rare association. Br J Dermatol 2002; 147:386.