Medline ® Abstract for Reference 45
of 'HLA and other susceptibility genes in rheumatoid arthritis'
45
TI
Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of patients with rheumatoid arthritis. Preferential relationship with HLA-Dw rather than HLA-DR specificities.
AU
Young A, Jaraquemada D, Awad J, Festenstein H, Corbett M, Hay FC, Roitt IM
SO
Arthritis Rheum. 1984;27(1):20.
Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. Dw4 and DR4 were strongly associated with severity of erosions when analysis was restricted to each of the following: patients with erosions, those under 50 at onset, and all females. Relationships were consistently stronger with Dw4 than with DR4. Another D-related specificity, MT3, was positively correlated and Dw2/DR2 negatively correlated with erosions.
AD
PMID