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Medline ® Abstract for Reference 73

of 'Hereditary pancreatitis'

Total pancreatectomy with islet autotransplantation: summary of a National Institute of Diabetes and Digestive and Kidney diseases workshop.
Bellin MD, Gelrud A, Arreaza-Rubin G, Dunn TB, Humar A, Morgan KA, Naziruddin B, Rastellini C, Rickels MR, Schwarzenberg SJ, Andersen DK
Pancreas. 2014 Nov;43(8):1163-71.
A workshop sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases focused on research gaps and opportunities in total pancreatectomy with islet autotransplantation (TPIAT) for the management of chronic pancreatitis (CP). The session was held on July 23, 2014, and structured into 5 sessions: (1) patient selection, indications, and timing; (2) technical aspects of TPIAT; (3) improving success of islet autotransplantation; (4) improving outcomes after totalpancreatectomy; and (5) registry considerations for TPIAT. The current state of knowledge was reviewed; knowledge gaps and research needs were specifically highlighted. Common themes included the need to identify which patients best benefit from and when to intervene with TPIAT, current limitations of the surgical procedure, diabetes remission and the potential for improvement, opportunities to better address pain remission, gastrointestinal complications in this population, and unique features of children with CP considered for TPIAT. The need for a multicenter patient registry that specifically addresses the complexities of CP and total pancreatectomy outcomes as well as postsurgical diabetes outcomes was repeatedly emphasized.
From the *Departments of Pediatrics and Surgery, University of Minnesota Medical School, Minneapolis, MN;†The Department of Medicine, Pritzker School of Medicine, Center for Endoscopic Research and Therapeutics, University of Chicago, Chicago, IL;‡The Divisions of Diabetes, Endocrinology and Metabolism and of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD;§The Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA;∥The Department of Surgery, Medical University of South Carolina, Charleston, SC;¶Baylor Simmons Transplant Institute, Dallas, TX; #The Department of Surgery, University of Texas Medical Branch, Galveston, TX; and **The Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.