HER2 and predicting response to therapy in breast cancer
- Hideko Yamauchi, MD
Hideko Yamauchi, MD
- Adjunct Instructor
- Department of Breast and Endocrine Surgery,
- Juntendo University School of Medicine
- Director of Breast Surgical Oncology
- Breast Center
- St. Luke's International Hospital
- Tokyo, Japan
- Daniel F Hayes, MD
Daniel F Hayes, MD
- Section Editor — Breast Cancer
- Professor of Medicine
- University of Michigan School of Medicine
Breast cancer is a heterogeneous, phenotypically diverse disease composed of several biologic subtypes that have distinct behavior. Amplification or overexpression of the human epidermal growth factor receptor 2 (HER2) oncogene is present in approximately 15 percent of primary invasive breast cancers . Women with both early-stage and metastatic breast cancer that meet criteria for HER2 positivity are treated with regimens including HER2-directed therapy.
Here we will review the definition of HER2 positivity, and the approach to HER2 discordance. Management of those with HER2-positive disease in the neoadjuvant, adjuvant, and metastatic settings, as well as treatment protocols for HER2-positive breast cancer, are discussed elsewhere:To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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