Hepatitis C virus infection in kidney donors
- Marion Muche, MD
Marion Muche, MD
- Charité - Medical University, Berlin, Germany
- Seema Baid-Agrawal, MD
Seema Baid-Agrawal, MD
- Associate Professor of Medicine
- Sahlgrenska Medical University, Gothenburg, Sweden
- Section Editors
- Daniel C Brennan, MD, FACP
Daniel C Brennan, MD, FACP
- Editor-in-Chief — Nephrology
- Section Editor — Renal Transplantation
- Professor of Medicine
- Medical Director and Co-Director of the Comprehensive Transplant Center, Department of Internal Medicine, Division of Nephrology
- Johns Hopkins Medical School
- Adrian M Di Bisceglie, MD
Adrian M Di Bisceglie, MD
- Section Editor — Hepatitis C
- Chief of Hepatology
- Saint Louis University School of Medicine
Transplantation of a kidney from a hepatitis C virus (HCV)-infected kidney donor may cause HCV infection in the recipient [1,2]. HCV infection has been associated with increased morbidity and possibly mortality in kidney transplant recipients [3-5].
These observations have led to the development of national and international policies concerning the allocation of organs from HCV-positive or negative donors into HCV-positive or negative recipients.
This topic reviews issues surrounding HCV-infected deceased or living kidney donors. HCV infection in kidney transplant recipients, transplant candidates, and nontransplant candidate dialysis patients is discussed elsewhere. (See "Hepatitis C infection in kidney transplant candidates and recipients" and "Hepatitis C virus infection in patients on maintenance dialysis".)
Methods of screening are discussed elsewhere. (See "Screening for chronic hepatitis C virus infection".)
The prevalence of HCV infection in the general population is approximately 2 to 3 percent worldwide, although prevalence varies from region to region . The best data regarding prevalence among deceased organ donors are from a study of 13,667 potential organ donors evaluated between 2004 and 2008 by 17 organ procurement organizations in the United States; HCV prevalence was 3.45 percent among normal-risk potential donors and 18.2 percent among high-risk potential donors . In one study of 55 living, related potential donors, the prevalence of HCV was 3.6 percent . The reported prevalence of HCV infection among renal transplant recipients is approximately 1.8 to 8 percent [9-13]. (See "Hepatitis C infection in kidney transplant candidates and recipients", section on 'Epidemiology'.)To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
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- TRANSMISSION OF HCV INFECTION BY KIDNEY TRANSPLANTATION
- OUTCOMES OF TRANSPLANTATION OF HCV-POSITIVE KIDNEY
- Compared with HCV-negative kidneys
- Compared with waitlisted patients
- Among HCV-positive recipients
- Among HCV-negative recipients
- IDENTIFICATION OF HCV INFECTION AMONG DONORS
- Deceased donors
- Living donors
- APPROACH TO THE USE OF KIDNEYS FROM DONORS WITH HCV INFECTION
- Deceased donors with HCV infection
- Living donors with HCV infection
- SOCIETY GUIDELINE LINKS
- SUMMARY AND RECOMMENDATIONS