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Hemostatic abnormalities in patients with liver disease

Authors
Neeral L Shah, MD
Stephen H Caldwell, MD
Section Editor
Lawrence LK Leung, MD
Deputy Editor
Jennifer S Tirnauer, MD

INTRODUCTION

Individuals with liver disease have a variety of hemostatic abnormalities, resulting in "rebalanced" hemostasis. These changes increase risks of bleeding as well as thrombosis. They become especially important in patients with bleeding and thrombotic risks such as gastrointestinal varices and vascular stasis, respectively. Management may be particularly challenging in individuals who require invasive procedures or anticoagulant therapy.

This topic discusses the hemostatic abnormalities in patients with liver disease and our approach to common clinical problems, including the roles of plasma products and prohemostatic factors, and the risks, prevention, and management of peripheral venous thrombosis.

Diagnosis and management of portal vein thrombosis, liver injury, cirrhosis, and liver disease from alcohol use are discussed in separate topic reviews:

(See "Acute portal vein thrombosis in adults: Clinical manifestations, diagnosis, and management".)

(See "Chronic portal vein thrombosis in adults: Clinical manifestations, diagnosis, and management".)

                               

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Literature review current through: Nov 2016. | This topic last updated: Fri Nov 04 00:00:00 GMT+00:00 2016.
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