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Hematopoietic cell transplantation in classical Hodgkin lymphoma

Author
Ginna G Laport, MD
Section Editor
Nelson J Chao, MD
Deputy Editor
Alan G Rosmarin, MD

INTRODUCTION

Among patients with Hodgkin lymphoma (HL, formerly called Hodgkin's disease) who undergo initial remission induction, the rate of relapse is approximately 10 to 20 percent in stage I-II disease and 30 to 40 percent in advanced disease. In addition, approximately 10 to 15 percent of patients have primary refractory disease and experience progression after an initial partial response. When feasible, a biopsy is strongly recommended when a patient has persistent or relapsed disease.

High dose chemotherapy and autologous hematopoietic cell transplantation (HCT) should be considered as the treatment of choice for the following subsets of patients:

Primary refractory disease (ie, induction failure)

Relapse after frontline conventional therapy

Issues related to high dose chemotherapy followed by autologous HCT will be reviewed here. The general approach to the treatment of patients with HL who relapse after initial chemotherapy is discussed separately, as are specific chemotherapy regimens and biologic therapy used in this setting. (See "Treatment of relapse of classical Hodgkin lymphoma after initial chemotherapy" and "Second and third line chemotherapy regimens and biologic therapy for relapsing or resistant classical Hodgkin lymphoma".)

                          

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Literature review current through: Nov 2016. | This topic last updated: Tue May 17 00:00:00 GMT 2016.
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